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Efficiacy results were analysed based on the reported efficacy estimand (calculated from data gathered while patients received their assigned randomized treatment, excluding data after discontinuing the allotted medication or after adding rescue medication

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In contrast, a higher degree of lixisenatide-stimulated GLP-1Rs tended to progressively co-localise post-endocytosis with the lysosomotropic fluorescent probe Lysotracker, indicating preferential targeting of the receptor towards a degradative pathway