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Therapeutic tolerability A systematic review of 39 randomised controlled trials demonstrated a class effect, with increased risk for nausea, vomiting, diarrhoea, and constipation compared with placebo in individuals without diabetes
has received honoraria and travel grants from Astra Zeneca, Eli Lilly, Merck Sharp & Dohme, Novartis, Takeda and Sanofi
A numbing cream is used to minimise discomfort, and most people find the treatment manageable
FDA-approved peptides like semaglutide (Wegovy, Ozempic) and tirzepatide (Mounjaro, Zepbound) have undergone extensive clinical trials
Deoxycholate has a critical micelle concentration (CMC) that can vary based on temperature, but the concentration we used (1 mM) is below the CMC and can be removed by dialysis 34
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