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Following subcutaneous injection, the peptide enters systemic circulation with bioavailability of 14-19% in rats, while intramuscular administration achieves 45-51% bioavailability in beagle dogs, indicating both route-dependent and species-dependent absorption characteristics

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They also cited a study of more than 25,000 subjects that found a 3.5-fold increase in intestinal obstruction rates for people who took GLP-1 RA drugs

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