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Some patients may benefit from dose escalation under medical supervision, though this must be balanced against the risk of gastrointestinal adverse effects such as nausea, vomiting, and diarrhoea
One widely used inbred strain(BTBR T + Itpr3tf/J) BTBR miceexhibits behavioral phenotypes similar to patients with ASD (Nadeem et al., 2019
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Signals fullness to the brain reduces appetite and food noise 2
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