I do feel like my brain fog is gone, the memory lapses Ive had since surgery in 2018 when I was under anesthesia for over 5 hours
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Its important to talk to your doctor before taking this peptide for dosage instructions and recommendations
Neelakantan et al., NNMT inhibition reverses diet-induced obesity in mice (2018) Babula et al., NNMT inhibition mitigates obesity-related metabolic dysfunction: fat mass, glucose tolerance, hepatic steatosis, pharmacokinetics and off-target screen (Diabetes Obes Metab, 2024) Dimet-Wiley et al., NNMT inhibition mimics and boosts exercise-mediated muscle improvements in aged mice (Sci Rep, 2024) NNMT inhibition and muscle function in aged mice (2019) Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice (2022): the diet-switch combination study Awosemo et al., rat pharmacokinetics of 5-amino-1MQ (2021) NNMT in metabolism and disease: review Sigma-Aldrich: 5-Amino-1MQ iodide product data (CAS 42464-96-0) FDA: bulk drug substances used in compounding under section 503A Disclaimer: Informational and research purposes only, not medical advice
What makes it relevant to obesity research
The mechanism sits upstream of anything you can feel: blocking NNMT stops nicotinamide being methylated into 1-MNA, which raises intracellular NAD+ and SAM and suppresses fat-cell lipogenesis