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In placebo-controlled trials, cholelithiasis was reported in 1.5% and 0.4% of patients-treated with GLP-1 Meds
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The Danger: If the body creates antibodies against exogenous DSIP, these antibodies might cross-react with endogenous DSIP (or DSIP-like proteins/GILZ)
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NO/cGMP pathway, RhoA/ROCK pathway, endothelium-derived vasoactive factors, testosterone level, oxidative stress, programmed cell death, etc
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