Genetics Your genes determine your appetite, satiety, cravings, body fat distribution, and metabolism
By activating areas of your brain that regulate appetite, Saxenda may make you feel less hungry, which as a result, can lead to lower calorie intake and weight loss
Drug class Thiazide diuretic Mechanism of action Inhibits Na/Cl symporter in the distal convoluted tubule of the kidney Excretion of sodium and water blood volume blood pressure excretion of potassium, magnesium excretion of calcium (can help prevent kidney stones) Clinical uses Hypertension (first-line therapy) Edema (heart failure, nephrotic syndrome, cirrhosis) Prevention of calcium kidney stones Pharmacokinetics Well absorbed orally Renally excreted unchanged Not a prodrug Adverse effects Hypokalemia Hyponatremia Hyperuricemia gout Hyperglycemia (mild) Hypotension Hypercalcemia Contraindications / Caution Severe renal impairment Hypersensitivity to sulfonamides Hydrochlorothiazide = Active drug Chlorthalidone = Active drug Metolazone = Active drug Thiazide diuretics work directly
- triglycerides down 37% - non-HDL cholesterol 16.5% - systolic blood pressure down 9.3 mmHg - waist circumference down 7.5 inches - hsCRP down 51.2% GI side effects were common as you'd expect
Anorexia nervosa Anorexia nervosa is characterized by an intense fear of gaining weight, a distorted body image, and extreme restriction of food intake leading to dangerously low body weight
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