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Acetoacetate can undergo spontaneous decarboxylation to acetone, or be enzymatically converted to -hydroxybutyrate (BHB) through the action of mitochondrial -hydroxybutyrate dehydrogenase which is encoded by the BDH1 gene
Mice with more fat had more NNMT
in Biochemical Pharmacology (2018)
That said, safety is generally a function of health and dosage, so it is important that you speak with a registered healthcare provider before beginning the therapy to rule out any contraindications and get ongoing evaluation of your progress
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