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The most common side effects are gastrointestinal, including nausea (12-31%), diarrhea (12-23%), vomiting (5-12%), and constipation (5-17%)

When GH levels rise adequately, natural feedback mechanisms prevent overproduction

For instance, persistent nausea and vomiting on Wegovy could indicate the need for dose reduction, and masking these symptoms with symptomatic treatment might lead to continued discomfort or complications such as dehydration

Both mazdutide and retatrutide should be stored as lyophilized powder at -20C for long-term storage, or refrigerated at 2-8C after reconstitution

But drinking enough water throughout the day can help reduce unnecessary snacking, improve digestion, and support overall metabolic function

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