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These regulatory mechanisms include PTMs, interactions with co-regulators and target DNA sequences, stability and turnover control, association with the Mediator complex, and regulation of RNA polymerase activity

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However, in rare casessuch as patients with kidney disease or specific hereditary disorders related to vitamin B12 metabolismhigh doses or inappropriate use could potentially cause complications

Metformin is an oral antidiabetic medication that has been used for decades to treat type 2 diabetes

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Severe abdominal pain, persistent vomiting preventing fluid intake, or signs of dehydration require urgent medical assessment to exclude pancreatitis or gallbladder complications