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Blood 94:66a, 1999

Disruptions in GSH synthesis and changes in the GSH/GSSG ratio are common for many pathological conditions, including malignant neoplasms

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Along with the apoplast, some intracellular compartments might also be deficient in the ascorbateglutathione pathway, in part to allow them to function in a more oxidizing environment

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Its effects on reducing corticotropin levels suggest involvement in stress-adaptive pathways, adding complexity to its pharmacological profile beyond simple sleep induction