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Retatrutide has shown higher weight loss results in clinical trials, with an average of up to 24% body weight reduction, compared to around 15% with semaglutide

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But estimated annual national health care expenditures associated with hypertension alone were about $219 billion in the United States in 2019 (6) a condition heavily driven by obesity

Because gut function often affects mood, stress, and cognition, this peptides dual action could be beneficial for those with gut-related anxiety or fatigue