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GLP-1s have also been shown to help prevent cardiovascular disease, improve weight loss, decrease progression of chronic kidney disease, and may even have neuroprotective effects in patients with Alzheimers disease

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Dapagliflozin 10 mg as monotherapy also provided statistically significant improvements in FPG and statistically significant reduction in body weight compared with metformin HCl alone and was non-inferior to metformin HCl extended-release monotherapy in lowering HbA1c

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Where evidence is absent, that gap is stated plainly

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