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From this list, three top candidates were selected for evaluation in mice using the ex vivo mycobacterial growth inhibition assay (MGIA), with one antigen, metE, emerging as a promising candidate due to its strong immunogenic profile
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These mixed responses cannot be generalized, but the fact that a subset experience real improvement makes this an important signal to investigate
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Trials will need to follow endocrine shifts, reproductive results, and off-target implications for years, not weeks
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