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The primary analysis consisted of 199 placebo-controlled clinical studies with a total of 27,863 patients in drug treatment groups and 16,029 patients in placebo groups (5 years of age and older)

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Standing Committee on the Scientific Evaluation of Dietary Reference Intakes - Panel on Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids and the Subcommittee on Upper Reference Levels of Nutrients, Food and Nutrition Board, Institute of Medicine (IOM)

Vomiting occurs in 17%, primarily concentrated during the peak weeks 6-8 period

The sensation is said to go away within an hour or so (similar to a niacin flush)

Contraindications and Precautions Several important contraindications and precautions should be considered for both peptides