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TAS2Rs, particularly in enteroendocrine cells, are involved in the release of GLP-1

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Research published in Redox Biology found that when cells were exposed to stress, older cells' glutathione levels plummeted to just 10% of their original levels, while younger cells maintained at least 35% of their glutathione

Structured Tapering Patients transitioning off higher GLP-1 doses may benefit from gradual reduction rather than abrupt discontinuation

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They should be used cautiously in patients with gastro-oesophageal reflux disease