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doi: 10.1016/j.cell.2017.09.021 151 JiangQYinXLillMADanielsonMLFreiserHHuangJ

These medications are contraindicated in patients with: Personal history of medullary thyroid carcinoma Family history of medullary thyroid carcinoma Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) For patients with standard hypothyroidism (typically autoimmune thyroiditis or post-ablation), these contraindications do not apply

Renal Function: Monitor in patients with renal impairment

This selective action ensures that during caloric deficits, the body prioritizes fat burning over muscle breakdown, helping maintain lean muscle tissue while reducing fat

In another study involving more than 96,000 patients initiating GLP-1s, 46% of patients with and 65% without Type 2 diabetes discontinued the drugs within one year