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26 Only two of the reviewed studies were RCTs of B12 on its own in children with ASD, both using subcutaneous methyl-B12

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The peptide demonstrates effectiveness across an unusually wide dose range in animal studies, with doses from 10 ng/kg to 10 mcg/kg showing comparable efficacy

Post-Market Surveillance Gap: Because AOD-9604 never received FDA approval for any indication, there is no post-market surveillance system capturing safety signals from widespread clinical use

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More rapid losses often reflect water rather than fat and may not persist