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As IKK- is the direct upstream kinase that phosphorylates IB-, leading to its degradation, we next examined whether decreased TNF-induced IB- phosphorylation by H 2 O 2 treatment was due to its effects on IKK- activity
352 Mutations in UCHL1, which encodes a deubiquitinating enzyme critical for ubiquitin recycling and proteasome efficiency, are associated with rare progressive neurodegenerative syndromes
However, as analogs were identified with improved cAMP potency in the BETP-sensitized assay, we also observed a gradual increase in signaling efficacy in the absence of BETP (Fig
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