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primary metabolic transformation occurs in intestinal microbiota Bacterial trimethylamine (TMA) formation from excess dietary L-carnitine, subsequently oxidized to TMAO in liver Renal excretion: primary elimination route with efficient tubular reabsorption via OCTN2 Urinary excretion increases proportionally with plasma concentrations above renal threshold Plasma half-life: ~15 hours with normal renal function Elimination half-life extended in renal insufficiency These pharmacokinetic characteristics inform research protocol design, particularly regarding administration regimens, tissue sampling timepoints, and expected tissue concentrations in experimental models

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A 2026 systematic review and meta-analysis of controlled human trials found that allulose (and its cousin tagatose) meaningfully reduced the postprandial glucose response when used in place of added sugars, an effect that may be especially useful in the window right after a carbohydrate-rich meal