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In the liver, the 25-hydroxylase enzymes (CYP2R1 and CYP27A1) convert inactive cholecalciferol to 25(OH)VD 3 (calcidiol) by carbon 25 hydroxylation 14
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For people who prefer not to inject, this is a meaningful alternative
Several mouse and human in vivo studies have reported a metformin-associated reduction in DPP4 activity [5057]
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Hepatology (2020) 72:5871
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