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Moreover, pediatric MASLD is associated with T2DM, cardiovascular metabolism, and renal risk, 157 indicating that GLP-1RA can act as a metabolic modifier, thereby improving prognosis, especially in patients who have difficulty adhering to lifestyle changes
Age, genetic background, dietary patterns, lifestyle, medication exposure, and host immune status can all shape the baseline microbial ecosystem, causing the same microbial signal or intervention to perform differently across individuals [11, 369, 477]
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However, understanding how activation of the GLP-1R contributes to myocardial protection and decreases cardiac injury is challenging
