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1 Of particular interest in this article is the function of GLP-1 as a hormone released by the gut during periods of eating that then stimulates the secretion of insulin

Separate signaling cascades can also determine an increase of cytosolic Ca 2+ which includes the phosphorylation of PKA after GLP-1 receptor activation, the increase of phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) levels and the mobilization of Ca 2+ stores [33, 36]

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De Leo E, Taranta A, Raso R, Polishchuk E, DOria V, Pezzullo M, Goffredo BM, Cairoli S, Bellomo F, Battafarano G, Camassei FD, Del Fattore A, Polishchuk R, Emma F, Rega LR (2023) Genistein improves renal disease in a mouse model of nephropathic cystinosis: a comparison study with cysteamine

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No GI breakdown Consistent systemic delivery SQ or IM administration 1