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Do not wait until deficiency develops
Some grains, like breakfast cereals and nutritional yeast, are also fortified with the nutrient ( On the contrary, liquid vitamin B12 supplements are made synthetically in laboratories using microbes and other chemical processes
For those working with compounded formulations, proper handling is essential
Dosing protocols vary by study, and there is no standardized, medically approved dosing for anxiety specifically
"Cobalamin metabolism and its clinical aspects" (PDF)