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Insulin secretion becomes more glucose-dependent rather than basal, reducing the risk of hypoglycemia while simultaneously improving postprandial glucose control

Sometimes, the explanation is irritation due to location while other times there are concerning features

462 (96%) patients in the semaglutide 20 mg group and 471 (98%) in the semaglutide 10 mg group completed the trial

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Tirzepatide is a GLP-1 receptor agonist and GIP agonist, meaning it mimics two gut hormones that regulate glucose, insulin, and appetite