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10.3349/ymj.2019.60.1.10 8 FengW.QiaoJ.TanY.LiuQ.WangQ.YangB.et al (2024)

Mast cells are immune sentinels that release inflammatory mediators, such as histamine and cytokines, in response to perceived threats

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Reactive oxygen species, ionizing radiation, and certain chemicals can cause single- and double-strand breaks in DNA 3,4

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SCFA producing Lachnospiraceae and Ruminococcaceae were reduced in US combat veterans with cirrhosis and PTSD compared to those without PTSD, together with increased pathobionts Enterococcus and Escherichia/Shigella (Bajaj et al., 2019), suggesting these microbial changes may reflect or even exacerbate inflammation-driven psychiatric vulnerability