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The selectivity of FOXO4-DRI for senescent over non-senescent cells is mechanistically grounded: FOXO4 is expressed at low levels in most non-senescent adult cells, but is strongly upregulated in senescent cells

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[2] For a patient managing conditions like leaky gut syndrome, irritable bowel disease, or NSAID-induced gastric injury, oral capsule formulations may therefore be both effective and logistically simpler than injection