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In this study, WD-fed MC4R-KO mice showed characteristics similar to those of human patients with MASH, such as increased ALT, AST, TIMP-1, TG, TC, and insulin levels (Supplementary Table 1)

It is also important to consider the pharmacokinetics of both medications, as they differ in their half-lives and peak action times

Rapid escalation is discouraged for both medications

Tirzepatide works the same whether injected morning, afternoon, or evening

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