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Cytotoxicity was assessed by measuring lactate dehydrogenase release as previously described [15] and CSE treated cells under conditions tested did not have changes in cell viability that were statistically significantly different from controls and was greater than 85%

Barker PA, Mantyh P, Arendt-Nielsen L, et al

Holman RR, Paul SK, Bethel MA, et al

The study concluded that MCTs had a dose-related central nervous system toxicity in dogs

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