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Mitochondrial repair of 8-oxoguanine and changes with aging

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The positive effects of IGF-1 on the rats continued for months after the rats stopped getting the supplemental hormone, whereas the exercising rats immediately lost size and strength as soon as they stopped exercising. In another study the muscle fibers of 27-month old rats old age for rats that were given IGF-1 during middle age, exhibited no deterioration of muscle fibers that indicate the classic and inevitable signs of aging

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Guevara-Aguirre J, Rosenbloom AL, Vaccarello MA, Fielder PJ, de la Vega A, Diamond FB, Rosenfeld RG: Growth hormone receptor deficiency (laron syndrome): clinical and genetic characteristics

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