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Statistical methods The primary efficacy variable was mean HbA 1c change from baseline to week 24 in the modified intent to treat (mITT) population with last observation carried forward for the patients who discontinued prematurely, comparing acarbose group with voglibose group

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Each time the dose is increased as is typical in structured escalation protocols symptoms may temporarily return or worsen before settling again

However, noticeable weight loss typically takes a bit longer, often occurring within 12 to 16 weeks of consistent use

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Int J Agric Biol 11:639642 Saruhan N, Terzi R, Saglam A, Kadioglu A (2009) The relationship between leaf rolling and ascorbate-glutathione cycle enzymes in apoplastic and symplastic areas of Ctenanthe setosa subjected to drought Stress