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The NHS recommends 6-8 cups of fluid daily for most adults, though requirements may differ for those with certain medical conditions such as heart or kidney disease

Therap Adv Gastroenterol 2009;2:157-163

First, the optimization of the Nrf2 pathway through targeted drug delivery, e.g., lipid nanoparticles (LPNs) loaded with sulforaphane or bardoxolone methyl could enhance endothelial uptake while avoiding systemic side effects (Zhang et al., 2024), and LNPs conjugated to VCAM-1 antibodies for inflamed vasculature targeting (Gu et al., 2025)

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Additionally, protein-rich foods tend to be more satiating, helping to curb cravings and reduce overall calorie intake

Newer agents like retatrutide show even greater potential but are not yet commercially available