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15,20 Serious GI AEs, though uncommon, have also been reported with GLP-1 RA therapy, including gastroparesis, intestinal obstruction, pancreatitis, and colonic ischemia
Jordn J, Ruz-Moreno JM
The two rest days are not strictly necessary but are a common precaution to manage cumulative copper exposure over longer cycles
Indias drug regulator, the CDSCO, has stated that GLP-1 obesity drugs are approved with the condition that they be prescribed only by qualified specialists after proper evaluation, per PIB, Government of India, 2025-26
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