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(September 2000)
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This converts -tocopherol (vitamin E-OH) into tocopheroxyl radical (vitamin E-O)
67,505 Ulefnersen (ION-363), an antisense therapy targeting the FUS gene, is currently in Phase III trials for FUS-ALS
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49,54 In addition, the large size of mRNA and its susceptibility to degradation by nucleases result in low cellular uptake, further limiting its application
Wrinkle reduction: Badenhorst et al
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