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1 Affinati, Alison H et al

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Phosphodiesterase-4 inhibition alters gene expression and improves isoniazid-mediated clearance of Mycobacterium tuberculosis in rabbit lungs

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Additionally, both companies are trying to expand the indications for the use of the drugs beyond diabetes and obesity

Adding a third receptor target could theoretically create more adverse effects, but the clinical data shows comparable or even improved tolerability versus Semaglutide