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Islets were incubated in 0.3 ml EC1 or EC2 media (ESM Table 2) supplemented with glucose and other reagents as indicated
A synergistic action in which glucagon receptor activation enhances energy expenditure whilst GLP-1 receptor agonists reduce calorie intake and both GLP-1/GIP potentiate the incretin effect to modulate the diabetogenic effect of glucagon agonists
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doi: 10.1073/pnas.1415675112 49 ChiouHCLinMWHsiaoPJChenCLChiaoSLinTYet al
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