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Experimental trials in animals further conclude that L-carnitine supplementation can reduce lipid deposition and increase the metabolites related to -oxidation, which confirm the importance of L-carnitine in controlling oxidative stress, steatosis, and fibrosis in the liver (87, 99)

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This convergence of intracellular signaling architecture despite divergent extracellular binding mechanisms is a key insight from the orforglipron structural studies

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