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This preparation was used in in vitro assays on human fecal slurry while monitoring the levels of TMA released over time, and it was also tested in vivo in both Mus musculus C57BL/6 (FMO3 +/+ ) strain WT and C57BL/6 -Fmo3em1Smoc (KO) mouse models to measure the trimethylamine N-oxide (TMAO) and TMA levels in the blood and urine, along with gut microbiota analysis in feces via next-generation sequencing (NGS)

2022;159:e36574

Mood improvements may result from better glycaemic control, weight loss, improved physical health, and enhanced self-esteem rather than direct effects on serotonin or other mood-regulating neurotransmitters

Additional benefits: Improves sleep quality (3-5g before bed) Supports collagen synthesis (skin, joints, tendons) Reduces inflammation (inhibits NF-B signaling) 3

TRIUMPH-1 and SURMOUNT-1 used different patient populations, different trial durations (80 vs 72 weeks), and different protocols

Throughout the duration of my 90-day trial, I was pleasantly surprised