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Kanoski SE, Rupprecht LE, Fortin SM, et al
Direct stimulation of GLP-1R on cardiomyocytes increases cAMP and activates the PI3K/Akt pathway, thereby improving contractility and reducing apoptosis, which preserves left ventricular function and cardiac output (47)
Injection Site Reactions In ZEPBOUND-treated patients in a pool of Study 1 and 2, injection site reactions were more frequent in those with anti-tirzepatide antibodies (11.3%) compared to those who did not develop anti-tirzepatide antibodies (1%) [see Clinical Pharmacology (12.6)]
While not a primary treatment for cardiovascular conditions, Semaglutides ability to reduce the risk of major cardiovascular events makes it a valuable option for individuals with type 2 diabetes and existing cardiovascular risks
