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PIONEER 1 to 6 and 8 to 10 have been summarized in detail for this report (details for PIONEER 7 are provided in Appendix 3 as the intervention, semaglutide with flexible dosing, is not aligned with the criteria specified in the CADTH review protocol or the dosing recommended by Health Canada)

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A heart attack can occur during CHD when: (1) a plaque in a coronary artery is so large that it blocks blood flow to the heart, or (2) an unstable plaque ruptures and a piece of plaque or resulting blood clot blocks the flow of blood to the heart

However, clinical experience provides approximate equivalencies that help set expectations for where your therapeutic dose may land

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