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[9] [2] According to NICE guidance, patients with confirmed B12 deficiency and neurological involvement typically require more frequent initial dosing (alternate-day injections) until symptom improvement occurs

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Apesar de ser recomendvel o acompanhamento de um profissional, para ajusto individual de dosagem, dentro de um programa alimentar saudvel, pode-se iniciar o uso com 500 mg dirios, aumentando-o gradualmente aps um perodo de adaptao