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Mafune A, Iwamoto T, Tsutsumi Y, et al

Although the name can be a bit misleading, Glucagon-Like Peptide-1 agonists (GLP-1s) are diabetes drugs that mimic the natural gut hormone GLP-1, which, unlike glucagon, decreases your blood sugar and reduces glucagon, especially after meals

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The five-step study framework of this CEA is illustrated in Additional file 1: Fig

Collectively, the binding mode comparison of the three peptides bound by the same receptor demonstrates common structural features in ligand recognition and distinct conformational adaptability of GIPR, GLP-1R and GCGR in response to different agonist stimulation