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The activated Trem2 signal in stage 1 DAM facilitates transition to stage 2 DAM, which is characterized by an upregulation of lysosomal, phagocytic, and lipid metabolism pathway-related genes including cst7 and itgax

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And in vitro , metformin reduces the inflammatory activation of macrophages by interfering with the metabolic changes linked to inflammation (Xiong et al., 2021)