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Enhancing mitochondrial capacity through biogenesis is studied as a potential approach to support neuronal function under metabolic stress or increased cognitive demand

Sleep restriction increases appetite, impairs recovery, and shifts the partitioning of weight lost during a deficit toward lean mass and away from fat

Phase 2 and 3 studies, such as randomized controlled trials, have shown that these agents significantly reduce liver fat content, improve liver enzyme profiles, and promote histological improvements in patients with MASLD and MASH ( This integrated anti-inflammatory and anti-fibrotic action complements their metabolic benefits, positioning dual GLP-1 receptor agonists as promising agents in the comprehensive management of MASLD and its complications

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