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Fasano, A., Fiorentini, C., Donelli, G., Uzzau, S., Kaper, J
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Genetic variants in antioxidant enzyme genes (glutathione synthase, GPX, SOD) influence cellular glutathione production capacity
Randomized clinical trial of how long-term glutathione supplementation offers protection from oxidative damage and improves hba1c in elderly type 2 diabetic patients
481,482 (4) A fourth targeted drug approach is the activation of PPAR- in mature adipocytes that then induces altered expression of several genes (increased GLUT4 and adiponectin expression, along with decreased TNF-, IL-6 and leptin expression) involved in the insulin signaling cascade, thereby improving insulin sensitivity
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