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By the study's end at week 120, the semaglutide group had regained an average of 11.6 percentage points of lost weight against 1.9 percentage points in the placebo group, leaving net losses of 5.6% and 0.1% respectively from the study's start
Of further interest, the 7 newly formed interfacial salt bridges constitutes a structural electrostatic scaffold (Figures 6, 7, 8, 9, 10 and 11) at the binding interface of GLP-1R ECD and semaglutide analogue A747, which consists of three sets of interfacial salt bridges, as shown by three red numbers (1, 2 and 3) within black circles in Figures 9, 10 and 11
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