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There is compelling evidence, including low plasma levels of GSH [12, 13], and effective antioxidant therapies (both with GSH [14] and its precursor, N-acetylcysteine [14, 15]), of REDOX imbalance contributing to the pathophysiology of several brain conditions such as obsessive-compulsive disorder, schizophrenia, bipolar disorder, autism, trichotillomania, and neurodegenerative disorders (see refs

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3 Resistance is not a singular or static phenomenon but rather the culmination of complex, multilevel processes involving both tumor-intrinsic and tumor-extrinsic factors