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2023, doi: 10.1007/s12630-023-02549-5

Ramsey, K

This conclusion was also reached in another study (5)

[5] Through gene regulation, estradiol promotes vaginal epithelial maturation, supports collagen synthesis within skin, and contributes to nitric-oxide-mediated vasodilation, collectively providing mechanistic explanations for clinical benefits such as improved vulvovaginal comfort and reduction in hot-flash frequency

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