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The peptide's effects on endothelial function, including enhanced eNOS activity and improved endothelial integrity, may contribute to vascular protection

Start with lower doses when stacking

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In the phase 2 trial, 41% to 63% of participants receiving cagrilintide (0.3 to 4.5 mg) experienced gastrointestinal adverse events, compared to 32% with placebo

Clinical trials tested doses up to 1mg daily without significant adverse effects, but this does not mean higher doses produce better results or that exceeding researched doses is safe