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large human trials are not yet
Vitamin B12 is an important water-soluble vitamin that plays a central role in several aspects of health, including brain function, heart health, and the production of red blood cells and DNA
But chronic high-dose use may: Overstimulate metabolic pathways Alter methylation balance (since NNMT is tied to methyl donor cycling) Lead to unintended side effects like fatigue, irritability, or hormonal imbalance Stick to researched dosing windows (typically 1020 mg/day for short cycles in animal models) 2
For long-term storage, keep them in the freezer
L., Zhang, X., Xie, X
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